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It is estimated that, in the human interactome, PPI networks include about 650,000 contacts [38]
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Topics of Interest Cellular and molecular mechanisms of tumor microenvironment–driven cancer plasticity Tumor cell dissemination, invasion, and metastatic niche formation Stromal-tumor-immune cell crosstalk in cancer progression Metabolic reprogramming and nutrient competition within the TME Immune evasion, immunosuppression, and checkpoint regulation Extracellular matrix remodeling, mechanotransduction, and tissue stiffness Epithelial-mesenchymal transition (EMT), hybrid states, and phenotypic switching Therapy-induced adaptive phenotypes and drug resistance mechanisms Tumor dormancy, persistence, and metastatic reactivation Spatial transcriptomics, single-cell multi-omics, and in vivo imaging approaches Organoid, organ-on-chip, and computational models of TME dynamics Systems biology and AI-driven modeling of tumor ecosystem evolution Therapeutic targeting of TME-mediated signaling and adaptive pathways Translational strategies to overcome metastasis and therapy resistance This Collection focuses on how tumor microenvironmental signals shape metastatic competence, adaptive cancer cell states, and resistance-associated phenotypes across molecular, cellular, and systems scales
